组织器官发育和相关疾病的遗传调控团队
科研团队:组织器官发育和相关疾病的遗传调控
团队网站:/ldsys/main.htm
团队简介:
太阳成集团tyc151cc“组织器官发育和相关疾病的遗传调控”团队的主要研究方向为:1、生理和病理条件下血管新生的遗传调控;2、神经发育以及相关疾病的发病机制;3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选。团队在模式生物斑马鱼和小鼠模型上,利用多种遗传操作技术、活体成像、高通量测序等手段探索相关疾病的发病机制和干预的理论依据。
二、团队负责人简介:
刘东 博士, 教授, 博士生导师。江苏省杰出青年基金获得者、江苏省第五期“333高层次人才培养工程”培养对象、江苏省“六大人才高峰”高层次人才培养对象、获江苏省“双创计划”资助。他是美国心脏协会American Heart Association会员,中国解剖学会再生医学专业委员会委员,中国生物物理学会听觉分会委员,青年委员会常务委员。近三年来发表SCI论文30篇,累计影响因子超过130,其中以通讯作者发表SCI 论文20篇,其中包括知名杂志CardiovascularResearch、Cell Research和Oncogene等。近5年来以项目主持人身份获得共10项国家级、省部级科研以及人才项目资助。
三、团队成员:
石运伟 博士、助理研究员(神经再生重点实验室)
王新 实验师(神经再生重点实验室)
巩杰 博士,副教授,硕士生导师
段叙初 博士、讲师
魏官云 博士、讲师
蔡成芸 博士、讲师
王琤博士、讲师
卢晓凤 博士、讲师
郝文璟 博士、讲师
研究生:
钱付平
王晓宁
钱佩佩
赵金湘
徐梦婷
张旭
黄自刚
胡越波
客座研究人员:
秦银银(宿迁第一人民医院)
吕峰 博士(南通科技学院)
四、在研课题
2019-2022: 国家自然科学基金-面上项目:血管新生的遗传调控(刘东)
2016-2019: 国家自然科学基金-面上项目:血管新生的遗传调控(刘东)
2013-2015: 国家自然科学基金-青年项目:血管新生的遗传调控(刘东)
2018-2021: 江苏省自然科学基金-杰出青年基金项目:血管新生的遗传调控(刘东)
2012-2015: 江苏省自然科学基金-青年基金项目:血管新生的遗传调控(刘东)
2017-2020: 江苏省高校自然科学研究项目-重大项目:血管新生(刘东)
2016-2019: 江苏省“六大人才高峰”高层次人才培养对象:血管新生(刘东)
2014-2016: 江苏省“双创计划”博士计划,境外世界名校创新类计划(刘东)
2012-2014: 江苏省高校自然科学研究项目-面上项目:血管新生(刘东)
石运伟:国家自然科学基金-面上项目:
王新:国家自然科学基金-青年项目
巩杰:国家自然科学基金-青年项目
段旭初:国家自然科学基金-青年项目
魏官云:江苏省自然科学基金-青年基金项目
巩杰:江苏省自然科学基金-青年基金项目
段旭初:江苏省高校自然科学研究项目-面上项目
横向课题一:2018/08-2018/12,20万元
横向课题二:2018/09-2019/08,54万元
横向课题三:2017/02-2019/06,53万元
五、主要论文
1. You, B.; Pan, S.; Gu, M.; Zhang, K.; Xia, T.; Zhang, S.; Chen, W.; Xie, H.; Fan, Y.; Yao, H.; Cheng, T.; Zhang, P.; Liu, D.; You, Y., Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. J Extracell Vesicles 2022, 11 (5), e12221. (通讯作者)
2. You, B.; Xia, T.; Gu, M.; Zhang, Z.; Zhang, Q.; Shen, J.; Fan, Y.; Yao, H.; Pan, S.; Lu, Y.; Cheng, T.; Yang, Z.; He, X.; Zhang, H.; Shi, M.; Liu, D.; You, Y., AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells. Cancer Research 2022, 82 (5), 846-858. (通讯作者)
3. Li, N.; Zhou, P.; Tang, H.; He, L.; Fang, X.; Zhao, J.; Wang, X.; Qi, Y.; Sun, C.; Lin, Y.; Qin, F.; Yang, M.; Zhang, Z.; Liao, C.; Zheng, S.; Peng, X.; Xue, T.; Zhu, Q.; Li, H.; Li, Y.; Liu, L.; Huang, J.; Liu, L.; Peng, C.; Kaindl, A. M.; Gecz, J.; Han, D.; Liu, D.; Xu, K.; Hu, H., In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy. Brain 2021. (通讯作者)
4. Zhang, L.; Gao, Y.; Zhang, R.; Sun, F.; Cheng, C.; Qian, F.; Duan, X.; Wei, G.; Sun, C.; Pang, X.; Chen, P.; Chai, R.; Yang, T.; Wu, H.; Liu, D., THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis. PLoS Genet 2020, 16 (8), e1008953. (通讯作者)
5. Shi, Y.; Duan, X.; Xu, G.; Wang, X.; Wei, G.; Dong, S.; Xie, G.; Liu, D., A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis 2019, 22 (2), 211-221. (通讯作者)
6. Bao, L.; You, B.; Shi, S.; Shan, Y.; Zhang, Q.; Yue, H.; Zhang, J.; Zhang, W.; Shi, Y.; Liu, Y.; Wang, X.; Liu, D.; You, Y., Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10. Oncogene 2018, 37 (21), 2873-2889. (通讯作者)
7. Wang, F.; Liu, D.; Zhang, R. R.; Yu, L. W.; Zhao, J. Y.; Yang, X. Y.; Jiang, S. S.; Ma, D.; Qiao, B.; Zhang, F.; Jin, L.; Gui, Y. H.; Wang, H. Y., A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population. Cell discovery 2017, 3, 17026. (共同一作)
8. Wang, X.; Ling, C. C.; Li, L.; Qin, Y.; Qi, J.; Liu, X.; You, B.; Shi, Y.; Zhang, J.; Jiang, Q.; Xu, H.; Sun, C.; You, Y.; Chai, R.; Liu, D., MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. Cardiovascular research 2016, 110 (1), 140-50. (通讯作者)
9. Qi, J.; Dong, Z.; Shi, Y.; Wang, X.; Qin, Y.; Wang, Y.; Liu, D., NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell research 2016, 26 (12), 1349-1352. (通讯作者)
10. 高煜,刘家辉,王新,刘东,斑马鱼遗传操作进展,生物工程学报,2017, 33(10): 1674-1692 (通讯作者)
其他SCI论文:
1. Zheng, Y. Q.; Suo, G. H.; Liu, D.; Li, H. Y.; Wu, Y. J.; Ni, H., Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience 2022, 15, 848257. (通讯作者)
2. Zheng, S.; Tang, D.; Wang, X.; Liu, C.; Zuo, N.; Yan, R.; Wu, C.; Ma, J.; Wang, C.; Xu, H.; He, Y.; Liu, D.; Liu, S., Kif15 Is Required in the Development of Auditory System Using Zebrafish as a Model. Frontiers in molecular neuroscience 2022, 15, 844568. (通讯作者)
3. Xu, G.; Huang, Z.; Sheng, J.; Gao, X.; Wang, X.; Garcia, J. Q.; Wei, G.; Liu, D.; Gong, J., FGF binding protein 3 is required for spinal cord motor neuron development and regeneration in zebrafish. Exp Neurol 2022, 348, 113944. (通讯作者)
4. Wei, G.; Zhang, X.; Cai, C.; Sheng, J.; Xu, M.; Wang, C.; Gu, Q.; Guo, C.; Chen, F.; Liu, D.; Qian, F., Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Front Cell Neurosci 2022, 16, 840143. (通讯作者)
5. Sheng, J.; Xu, J.; Geng, K.; Liu, D., Sema6D Regulates Zebrafish Vascular Patterning and Motor Neuronal Axon Growth in Spinal Cord. Frontiers in molecular neuroscience 2022, 15, 854556. (通讯作者)
6. Sheng, J.; Gong, J.; Shi, Y.; Wang, X.; Liu, D., MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development. Open Biol 2022, 12 (4), 210315. (通讯作者)
7. Qian, P.; Kang, J.; Liu, D.; Xie, G., Single Cell Transcriptome Sequencing of Zebrafish Testis Revealed Novel Spermatogenesis Marker Genes and Stronger Leydig-Germ Cell Paracrine Interactions. Front Genet 2022, 13, 851719. (通讯作者)
8. Qian, F.; Jiang, X.; Chai, R.; Liu, D., The Roles of Solute Carriers in Auditory Function. Front Genet 2022, 13, 823049. (通讯作者)
9. Lv, F.; Ge, X.; Qian, P.; Lu, X.; Liu, D.; Chen, C., Neuron navigator 3 (NAV3) is required for heart development in zebrafish. Fish physiology and biochemistry 2022. (通讯作者)
10. Hu, S. Q.; Xu, H. M.; Qian, F. P.; Chen, C. S.; Wang, X.; Liu, D.; Cheng, L., Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis. Dev Neurobiol 2022, 82 (1), 88-97. (通讯作者)
11. Chen, C.; Liu, D., Establishment of Zebrafish Models for Diabetes Mellitus and Its Microvascular Complications. J Vasc Res 2022, 1-9. (通讯作者)
12. Zhou, J.; Liang, W.; Wang, J.; Chen, J.; Liu, D.; Wang, X.; Wu, Y.; Zhang, Q.; Shen, D., An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish. Human molecular genetics 2021.
13. Zheng, Y.; Zhao, J.; Li, J.; Guo, Z.; Sheng, J.; Ye, X.; Jin, G.; Wang, C.; Chai, W.; Yan, J.; Liu, D.; Liang, X., SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate. Int J Biol Macromol 2021, 193 (Pt B), 1124-1129. (通讯作者)
14. Zhang, K.; Liu, D.; Zhao, J.; Shi, S.; He, X.; Da, P.; You, Y.; You, B., Nuclear exosome HMGB3 secreted by nasopharyngeal carcinoma cells promotes tumour metastasis by inducing angiogenesis. Cell Death Dis 2021, 12 (6), 554. (共同一作)
15. Xie, G.; Zhang, X.; Lv, F.; Sang, M.; Hu, H.; Wang, J.; Liu, D., Nanopore Sequencing and Hi-C Based De Novo Assembly of Trachidermus fasciatus Genome. Genes (Basel) 2021, 12 (5). (通讯作者)
16. Shi, L.; Chen, C.; Yin, Z.; Wei, G.; Xie, G.; Liu, D., Systematic profiling of early regulators during tissue regeneration using zebrafish model. Wound Repair Regen 2021, 29 (1), 189-195. (通讯作者)
17. Pang, X. H.; Zheng, X. Y.; Lin, Y.; Zheng, H.; Xu, J.; Liu, D.; Jin, C. Y.; Zhang, L. P.; Zhang, Y. T.; Chu, J. S.; Chai, Y. C.; Yang, T., A Novel p.Tyr129His Variant in SIX1 Leads to Dominant, Delayed-onset Hearing Loss with Possible Association with Congenital Anosmia. Biomed Environ Sci 2021, 34 (4), 314-318.
18. Li, M.; Liu, J.; Liu, D.; Duan, X.; Zhang, Q.; Wang, D.; Zheng, Q.; Bai, X.; Lu, Z., Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways. J Cell Mol Med 2021, 25 (2), 975-989.
19. Hu, Z.; Zhang, C.; Wang, S.; Gao, S.; Wei, J.; Li, M.; Hou, L.; Mao, H.; Wei, Y.; Qi, T.; Liu, H.; Liu, D.; Lan, F.; Lu, D.; Wang, H.; Li, J.; Wang, Y., Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic acids research 2021, 49 (7), 4008-4019.
20. Gong, J.; Qian, P.; Hu, Y.; Guo, C.; Wei, G.; Wang, C.; Cai, C.; Wang, H.; Liu, D., Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish. Front Cell Dev Biol 2021, 9, 663995. (通讯作者)
21. Zhang, Z.; Hou, H.; Yu, S.; Zhou, C.; Zhang, X.; Li, N.; Zhang, S.; Song, K.; Lu, Y.; Liu, D.; Lu, H.; Xu, H., Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia 2020, 68 (1), 111-127.
22. Zhang, Y.; Wang, Y.; Yao, X.; Wang, C.; Chen, F.; Liu, D.; Shao, M.; Xu, Z., Rbm24a Is Necessary for Hair Cell Development Through Regulating mRNA Stability in Zebrafish. Front Cell Dev Biol 2020, 8, 604026.
23. Wang, B.; Xu, M.; Li, M.; Wu, F.; Hu, S.; Chen, X.; Zhao, L.; Huang, Z.; Lan, F.; Liu, D.; Wang, Y., miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7. Mol Ther Nucleic Acids 2020, 19, 1299-1308.
24. Shen, D.; Chen, J.; Liu, D.; Shen, M.; Wang, X.; Wu, Y.; Ke, S.; Macdonald, R. L.; Zhang, Q., The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA). Ann Transl Med 2020, 8 (23), 1560.
25. Qian, F.; Wang, X.; Yin, Z.; Xie, G.; Yuan, H.; Liu, D.; Chai, R., The slc4a2b gene is required for hair cell development in zebrafish. Aging (Albany NY) 2020, 12 (19), 18804-18821. (通讯作者)
26. Liu, C.; Zhao, J.; Zhang, X.; Wei, G.; Hao, W.; Wang, X.; Yang, C.; Shi, Y.; Liu, D., Biomass-derived cellulose nanoparticles display considerable neurotoxicity in zebrafish. Int J Biol Macromol 2020, 165 (Pt B), 1783-1792. (通讯作者)
27. Hu, Z.; Wang, S.; Zhang, C.; Gao, N.; Li, M.; Wang, D.; Wang, D.; Liu, D.; Liu, H.; Ong, S. G.; Wang, H.; Wang, Y., A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. PLoS Biol 2020, 18 (3), e3000686.
28. Gong, J.; Hu, S.; Huang, Z.; Hu, Y.; Wang, X.; Zhao, J.; Qian, P.; Wang, C.; Sheng, J.; Lu, X.; Wei, G.; Liu, D., The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish. Frontiers in molecular neuroscience 2020, 13, 34. (通讯作者)
29. Gao, C.; Guo, C.; Peng, Q.; Cao, J.; Shohat-Ophir, G.; Liu, D.; Pan, Y., Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival. Neuroscience bulletin 2020, 36 (12), 1429-1440.
30. Zhang, K.; Zhang, H.; Zhou, H.; Crookes, D.; Li, L.; Shao, Y.; Liu, D., Zebrafish Embryo Vessel Segmentation Using a Novel Dual ResUNet Model. Comput Intell Neurosci 2019, 2019, 8214975. (通讯作者)
31. Zhang, H.; Gao, Y.; Qian, P.; Dong, Z.; Hao, W.; Liu, D.; Duan, X., Expression analysis of Rab11 during zebrafish embryonic development. BMC Dev Biol 2019, 19 (1), 25.
32. Yu, B.; Yao, C.; Wang, Y.; Mao, S.; Wang, Y.; Wu, R.; Feng, W.; Chen, Y.; Yang, J.; Xue, C.; Liu, D.; Ding, F.; Gu, X., The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in Rats. Frontiers in molecular neuroscience 2019, 12, 287.
33. Wang, Y. M.; Zheng, Y. F.; Yang, S. Y.; Yang, Z. M.; Zhang, L. N.; He, Y. Q.; Gong, X. H.; Liu, D.; Finnell, R. H.; Qiu, Z. L.; Du, Y. S.; Wang, H. Y., MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ 2019, 26 (10), 1863-1879.
34. Wang, D.; Zhang, C.; Wang, B.; Li, B.; Wang, Q.; Liu, D.; Wang, H.; Zhou, Y.; Shi, L.; Lan, F.; Wang, Y., Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nat Commun 2019, 10 (1), 4284.
35. Shi, Y.; Wang, X.; Shi, Y.; Zhang, J.; Zhao, S.; Yin, Z.; Xu, G.; Duan, X.; Guo, Z.; Liang, X.; Liu, D., Two Compounds Isolated From Ganglioside GM1 Promote Angiogenesis in Zebrafish. J Cardiovasc Pharmacol 2019, 74 (1), 71-79. (通讯作者)
36. Qin, Y.; Wang, S.; Duan, X.; Liu, D., Expression analysis of the aquaporins during zebrafish embryonic development. Gene expression patterns : GEP 2019, 32, 38-43. (通讯作者)
37. Li, L.; Zhu, M.; Wu, W.; Qin, B.; Gu, J.; Tu, Y.; Chen, J.; Liu, D.; Shi, Y.; Liu, X.; Sang, A.; Ding, D., Brivanib, a multitargeted small-molecule tyrosine kinase inhibitor, suppresses laser-induced CNV in a mouse model of neovascular AMD. J Cell Physiol 2019.
38. Dong, Z.; Wu, S.; Zhu, C.; Wang, X.; Li, Y.; Chen, X.; Liu, D.; Qiang, L.; Baas, P. W.; Liu, M., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 2019, 20 (1), 71-81.
39. Yan, W.; Liu, W.; Qi, J.; Fang, Q.; Fan, Z.; Sun, G.; Han, Y.; Zhang, D.; Xu, L.; Wang, M.; Li, J.; Chen, F.; Liu, D.; Chai, R.; Wang, H., A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro. Molecular neurobiology 2018, 55 (3), 2070-2084. (通讯作者)
40. Shan, Y.; You, B.; Shi, S.; Shi, W.; Zhang, Z.; Zhang, Q.; Gu, M.; Chen, J.; Bao, L.; Liu, D.; You, Y., Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases. Cell Death Dis 2018, 9 (3), 382. (通讯作者)
41. Li, B.; Yu, L.; Liu, D.; Yang, X.; Zheng, Y.; Gui, Y.; Wang, H., MIB1 Mutations Reduce Notch Signaling Activation and Contribute to Congenital Heart Disease. Clin Sci (Lond) 2018.
42. Gong, J.; Chai, L.; Xu, G.; Ni, Y.; Liu, D., The expression of natriuretic peptide receptors in developing zebrafish embryos. Gene expression patterns : GEP 2018, 29, 65-71. (通讯作者)
43. Zhang, J.; Qi, J.; Wu, S.; Peng, L.; Shi, Y.; Yang, J.; Yin, Z.; Gao, Y.; Wang, C.; Gong, J.; Zhang, H.; Zhang, J.; Liu, D., Fatty Acid Binding Protein 11a Is Required for Brain Vessel Integrity in Zebrafish. Frontiers in physiology 2017, 8, 214. (通讯作者)
44. Xie, Y.; Wang, D.; Lan, F.; Wei, G.; Ni, T.; Chai, R.; Liu, D.; Hu, S.; Li, M.; Li, D.; Wang, H.; Wang, Y., An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells. Scientific reports 2017, 7 (1), 2320.
45. Mu, Z.; Zhang, S.; He, C.; Hou, H.; Liu, D.; Hu, N.; Xu, H., Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience bulletin 2017, 33 (1), 53-61.
46. Lv, F.; Zhu, C.; Yan, X.; Wang, X.; Liu, D., Generation of a mef2aa:EGFP transgenic zebrafish line that expresses EGFP in muscle cells. Fish physiology and biochemistry 2017, 43 (1), 287-294. (通讯作者)
47. Jin, D.; Zhu, D.; Fang, Y.; Chen, Y.; Yu, G.; Pan, W.; Liu, D.; Li, F.; Zhong, T. P., Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics 2017, 44 (10), 483-492.
48. He, Z.; Guo, L.; Shu, Y.; Fang, Q.; Zhou, H.; Liu, Y.; Liu, D.; Lu, L.; Zhang, X.; Ding, X.; Liu, D.; Tang, M.; Kong, W.; Sha, S.; Li, H.; Gao, X.; Chai, R., Autophagy protects auditory hair cells against neomycin-induced damage. Autophagy 2017, 1-21.
49. He, Y.; Lu, X.; Qian, F.; Liu, D.; Chai, R.; Li, H., Insm1a Is Required for Zebrafish Posterior Lateral Line Development. Frontiers in molecular neuroscience 2017, 10, 241.
50. Gong, J.; Wang, X.; Zhu, C.; Dong, X.; Zhang, Q.; Wang, X.; Duan, X.; Qian, F.; Shi, Y.; Gao, Y.; Zhao, Q.; Chai, R.; Liu, D., Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in molecular neuroscience 2017, 10, 274. (通讯作者)
51. Zhang, S.; Mu, Z.; He, C.; Zhou, M.; Liu, D.; Zhao, X. F.; Goldman, D.; Xu, H., Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Muller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science 2016, 57 (4), 1991-2000.
52. Wang, X.; Yuan, W.; Wang, X.; Qi, J.; Qin, Y.; Shi, Y.; Zhang, J.; Gong, J.; Dong, Z.; Liu, X.; Sun, C.; Chai, R.; Le Noble, F.; Liu, D., The somite-secreted factor Maeg promotes zebrafish embryonic angiogenesis. Oncotarget2016, 7 (47), 77749-77763. (通讯作者)
53. Shi, Y. W.; Yuan, W.; Wang, X.; Gong, J.; Zhu, S. X.; Chai, L. L.; Qi, J. L.; Qin, Y. Y.; Gao, Y.; Zhou, Y. L.; Fan, X. L.; Ji, C. Y.; Wu, J. Y.; Wang, Z. W.; Liu, D., Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronal apoptosis in zebrafish. Scientific reports 2016, 6, 30189. (通讯作者)
54. He, Z.; Zhang, S.; Song, Q.; Li, W.; Liu, D.; Li, H.; Tang, M.; Chai, R., The structural development of primary cultured hippocampal neurons on a graphene substrate. Colloids and surfaces. B, Biointerfaces 2016, 146, 442-51.
55. Wang, X.; Wang, X.; Yuan, W.; Chai, R.; Liu, D., Egfl6 is involved in zebrafish notochord development. Fish physiology and biochemistry 2015, 41 (4), 961-9. (通讯作者)
56. Wang, X.; Chong, M.; Wang, X.; Wang, H.; Zhang, J.; Xu, H.; Zhang, J.; Liu, D., Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In vitro cellular & developmental biology. Animal 2015, 51 (3), 211-7.
57. Xu, M.; Liu, D.; Dong, Z.; Wang, X.; Wang, X.; Liu, Y.; Baas, P. W.; Liu, M., Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton 2014, 71 (10), 555-63.
58. Wang, X.; Li, L.; Liu, D., Expression analysis of integrin beta1 isoforms during zebrafish embryonic development. Gene expression patterns : GEP 2014, 16 (2), 86-92. (通讯作者)
59. Sang, Q.; Zhang, J.; Feng, R.; Wang, X.; Li, Q.; Zhao, X.; Xing, Q.; Chen, W.; Du, J.; Sun, S.; Chai, R.; Liu, D.; Jin, L.; He, L.; Li, H.; Wang, L., Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Human molecular genetics 2014, 23 (23), 6201-11.
60. Li, S.; Liu, Q.; Wang, Y.; Gu, Y.; Liu, D.; Wang, C.; Ding, G.; Chen, J.; Liu, J.; Gu, X., Differential gene expression profiling and biological process analysis in proximal nerve segments after sciatic nerve transection. PLoS One 2013, 8 (2), e57000.
61. Jiang, Q.; Lagos-Quintana, M.; Liu, D.; Shi, Y.; Helker, C.; Herzog, W.; le Noble, F., miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension 2013, 62 (3), 592-8.
62. Huang, Y.; Wang, X.; Xu, M.; Liu, M.; Liu, D., Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Gene expression patterns : GEP 2013, 13 (7), 265-70.
63. Liu, D.; Krueger, J.; Le Noble, F., The role of blood flow and microRNAs in blood vessel development. Int J Dev Biol 2011, 55 (4-5), 419-29.
64. Krueger, J.; Liu, D.; Scholz, K.; Zimmer, A.; Shi, Y.; Klein, C.; Siekmann, A.; Schulte-Merker, S.; Cudmore, M.; Ahmed, A.; le Noble, F., Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development 2011, 138 (10), 2111-20.
65. Klein, C.; Mikutta, J.; Krueger, J.; Scholz, K.; Brinkmann, J.; Liu, D.; Veerkamp, J.; Siegel, D.; Abdelilah-Seyfried, S.; le Noble, F., Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis. Development 2011, 138 (10), 1935-45.
66. Jiang, Q.; Liu, D.; Sun, S.; Hu, J.; Tan, L.; Wang, Y.; Gui, Y.; Yu, M.; Song, H., Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis. Fish physiology and biochemistry 2010, 36 (4), 945-51.
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中文论文:
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2. 吕峰,石运伟,王新,刘东,严兴洪,microRNA-10a/b通过抑制Mib1调节斑马鱼神经元的发育,中国细胞生物学学报,2017, 39(2): 191–196 (通讯作者)
3. 王鸿奎,王学谦,王新,袁玮,刘东,非肌性肌球蛋白II-B调节斑马鱼咽弓的发育, 解剖学报,2016, 47(1):113-116 (通讯作者)
4. 袁玮,浦超,Rupesh Puri,石运伟,王新,李石营,刘东,Non-muscle Myosin II-A调节斑马鱼胚胎发育过程中肠内分泌细胞的极化,中国细胞生物学报,2015, 37(3): 328–334 (通讯作者)
5. 王新,张素珍,王学谦,李丽萍,张晶晶,刘东,流式细胞仪分选转基因斑马鱼胚胎荧光标记细胞的一种快速方法,中国细胞生物学报,2014, 36(3): 356–360 (通讯作者)
6. 刘雪静,王雪雯,石运伟,王新,高煜,刘东,生长激素促进斑马鱼尾鳍的再生,中国实验动物学报,2019, 27(2): 154–159 (通讯作者)
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